ML-161

ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM. It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA (Cay-10008014), U-46619 (Cay-16450), or collagen.Formal Name: 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide. CAS Number: 423735-93-7. Synonyms: AG-670, CID-1048267. Molecular Formula: C17H17BrN2O2. Formula Weight: 361.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 240 nm. SMILES: BrC1=C(C(NC2=CC=CC(NC(CCC)=O)=C2)=O)C=CC=C1. InChi Code: InChI=1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22). InChi Key: DFOVLSMXPWPCFH-UHFFFAOYSA-N.