MK2-IN-1 hydrochloride

Description: MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 µM) [1]. Target: MAPK, HSP. Smiles: Cl.Clc1ccc(cc1)-c1ccc(o1)C(=O)N(Cc1ccccn1)c1ccc(cc1)N1CCNCC1. References: Huang X, Shipps Jr G W, Cheng C C, et al. Discovery and hit-to-lead optimization of non-ATP competitive MK2 (MAPKAPK2) inhibitors[J]. ACS medicinal chemistry letters, 2011, 2(8): 632-637.