MK-8745

MK-8745 is an Aurora A kinase inhibitor (IC50 = 0.6 nM) that is selective for Aurora A over Aurora B kinase (IC50 = 280 nM). It induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells when used at a concentration of 1 µM. MK-8745 (5 µM) induces apoptosis and polyploidy in p53-positive and -negative HCT116 colon cancer cells, respectively. It also induces apoptosis in sarcoma, melanoma, and pancreatic cancer cell lines in a p53-dependent manner when used at a concentration of 5 µM.Formal Name: (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone. CAS Number: 885325-71-3. Molecular Formula: C20H19ClFN5OS. Formula Weight: 431.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml. lambdamax: 274, 318 nm. SMILES: ClC1=CC=CC(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=C1F. InChi Code: InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25). InChi Key: YCRFPWKUUNKNDN-UHFFFAOYSA-N.