MK-0893

A GCGR antagonist (IC50 = 15.7 nM), selective for GCGR over GIPR, GLP-1R, PAC1, VPAC1, and VPAC2 (IC50s = 1,020, >10,000, 9,200, 11,580, and 12,800 nM, respectively), reduces glucagon-induced increases in blood glucose levels in rhesus monkeys at 1 and 3 mg/kg. SMILES: O=C(NCCC(O)=O)C1=CC=C([C@H](C)N2C(C3=CC=C(C=C(OC)C=C4)C4=C3)=CC(C5=CC(Cl)=CC(Cl)=C5)=N2)C=C1. InChi Code: InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)/t19-/m0/s1. InChi Key: DNTVJEMGHBIUMW-IBGZPJMESA-N