Zu "K04583" wurden 74 Artikel gefunden!
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NEU
MK-0893
Artikelnummer: Cay28923-1
A GCGR antagonist (IC50 = 15.7 nM), selective for GCGR over GIPR, GLP-1R, PAC1, VPAC1, and VPAC2 (IC50s = 1,020, >10,000, 9,200, 11,580, and 12,800 nM, respectively), reduces glucagon-induced increases in blood glucose levels in rhesus monkeys at 1 and 3 mg/kg. SMILES:...
| Schlagworte: | N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-beta-alanine |
| Anwendung: | GCGR antagonist |
| CAS | 870823-12-4 |
| MW: | 588.48 D |
ab 107,00 €
CHO-K1/GCGR/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00345
Recombinant CHO-K1 cells stably overexpress human glucagon receptor (GCGR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.
| Schlagworte: | GCGR, Glucagon receptor |
11.424,00 €
HEK293/GCGR/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00422
Recombinant HEK293 cells stably overexpress human glucagon receptor (GCGR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.
| Schlagworte: | GCGR, Glucagon receptor |
11.424,00 €
GCGR/Glucagon receptor, His & Avi, Human
Artikelnummer: GSC-Z05335-100
The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed...
| Schlagworte: | GCGR, Glucagon receptor |
| Ursprungsart: | human |
| MW: | 15.96 kD |
ab 578,00 €
GCGR/Glucagon receptor hFc Chimera, Human
Artikelnummer: GSC-Z05336-100
The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed...
| Schlagworte: | GCGR, Glucagon receptor |
| Ursprungsart: | human |
| MW: | 39 kD |
ab 578,00 €
Bamadutide
Artikelnummer: Cay41269-1
Bamadutide is a peptide agonist of glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP accumulation in HEK293 cells expressing human GCGR or GLP-1R (EC50s = 1 and 3.5 pM, respectively). Bamadutide (0.1 mg/kg) reduces food intake in female mice. It decreases blood levels of glucose...
| Schlagworte: | SAR425899,... |
| Anwendung: | GCGR / GLP-1R peptide agonist |
| CAS | 1596343-09-7 |
| MW: | 4440 D |
ab 118,00 €
Glucagon Receptor Antagonist 2
Artikelnummer: Cay41242-1
A glucagon receptor antagonist
| Schlagworte: | GCGR Antagonist II,... |
| Anwendung: | Glucagon receptor antagonist |
| CAS | 202917-18-8 |
| MW: | 359.48 D |
ab 83,00 €
Adomeglivant
Artikelnummer: Cay29668-5
Adomeglivant is an allosteric antagonist of the glucagon receptor. It inhibits glucagon-induced increases in cAMP levels in HEK293 cells expressing the rat glucagon or GLP-1 receptors (IC50s = 1.8 and 1.2 µM, respectively) but has no effect on cAMP levels when used alone. Adomeglivant also inhibits increases in cAMP...
| Schlagworte: | LY2409021,... |
| Anwendung: | Allosteric glucagon receptor antagonist |
| CAS | 1488363-78-5 |
| MW: | 555.6 D |
ab 49,00 €
Glucagon Receptor Antagonist 3
Artikelnummer: Cay41243-1
Glucagon receptor antagonist 3 is an antagonist of the glucagon receptor.Formal Name: (alphaR,4R)-rel-4-(4-fluoro-2-hydroxyphenyl)-alpha-methyl-2,6-bis(1-methylethyl)-5-propyl-3-pyridinemethanol. CAS Number: 202917-17-7. Molecular Formula: C22H30FNO2. Formula Weight: 359.5. Purity: >95%. Formulation: (Request...
| Schlagworte: | (alphaR,4R)-rel-4-(4-fluoro-2-hydroxyphenyl)-alpha-methyl-2,6-bis(1-methylethyl)-5-propyl-3-pyridinemethanol |
| Anwendung: | Glucagon receptor antagonist |
| CAS | 202917-17-7 |
| MW: | 359.5 D |
ab 147,00 €
Skyrin
Artikelnummer: AG-CN2-0001-M001
Non-peptidic anti-diabetic agent, Receptor-selective glucagon antagonist, Free radical species (.OH, R.) and singlet oxygen (1O2) scavenger, Mycotoxin, Cytotoxic, Antioxidant. Isolated from fungus Talaromyces sp.
| Schlagworte: | Rhodophyscin, Endothianin |
| Anwendung: | Antioxidant, Glucagon antagonist |
| CAS | 602-06-2 |
| MW: | 538,5 D |
176,00 €
![[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt)](https://www.biomol.com/media/image/08/2c/05/Cay24459-1_200x200.png "[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt)")
[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate...
Artikelnummer: Cay24459-1
[Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on...
| Schlagworte: | 9-L-glutamic acid-29-L-threoninamide-2-29-glucagon (swine) |
| Anwendung: | Peptide glucagon receptor antagonist |
| MW: | 3358.7 D |
523,00 €
Glucagon Receptor Antagonist 4
Artikelnummer: Cay22164-1
Glucagon receptor antagonist 4 is an antagonist of the glucagon receptor (GCGR, Ki = 14 nM for the human recombinant receptor). It is greater than 230-fold selective for GCGR over the glucagon-like peptide 1 (GLP-1) receptor, as well as a panel of 69 receptors, ion channels, uptake sites, and enzymes at 10 µM....
| Schlagworte: | GCGR Antagonist IV, N-[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy]butyl]benzoyl]-beta-alanine |
| Anwendung: | GCGR antagonist |
| CAS | 1393124-08-7 |
| MW: | 503.5 D |
ab 49,00 €