MK-0608

Description: MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 µM and EC90=1.3 µM in the subgenomic-replicon assay). Target: HCV Protease. Smiles: C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc12. References: Carroll SS, et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother. 2009 Mar,53(3):926-34.