Zu "K22472" wurden 24 Artikel gefunden!
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2'-O-Methylcytidine
Artikelnummer: Cay33411-1
2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B, IC50 = 3.8 µM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 µM).Formal Name: 2'-O-methyl-cytidine. CAS Number: 2140-72-9. Molecular Formula: C10H15N3O5. Formula Weight: 257.2....
| Schlagworte: | 2'-O-methyl-cytidine |
| Anwendung: | HCV NS5B inhibitor |
| CAS | 2140-72-9 |
| MW: | 257.2 D |
ab 44,00 €
Bemnifosbuvir hemisulfate
Artikelnummer: TGM-T9331-1mg
Description: Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication. Target: HCV Protease, SARS-CoV. Smiles:...
| Schlagworte: | AT-527 |
| Anwendung: | Targets Coronaviridae replicase polyprotein 1ab (pp1ab) |
| CAS | 2241337-84-6 |
| MW: | 1261.15 D |
ab 50,00 €
Lomibuvir
Artikelnummer: Cay26630-10
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV, Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).Formal Name:...
| Schlagworte: | VX-222,... |
| Anwendung: | Antiviral, NS5B polymerase inhibitor |
| CAS | 1026785-59-0 |
| MW: | 445.6 D |
ab 181,00 €
3'-Deoxy-3'-fluoroguanosine
Artikelnummer: Cay35699-10
3'-Deoxy-3'-fluoroguanosine is a nucleoside analog and an inhibitor of hepatitis C virus (HCV) RNA polymerase non-structural protein 5B (NS5B, IC50 = 1.8 µM).CAS Number: 123402-21-1. Molecular Formula: C10H12FN5O4. Formula Weight: 285.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility:...
| Anwendung: | HCV NS5B inhibitor, nucleoside analog |
| CAS | 123402-21-1 |
| MW: | 285.2 D |
ab 52,00 €
Lamevudine
Artikelnummer: Cay39925-10
Lamevudine is an antiviral. It selectively inhibits wild-type hepatitis C virus (HCV) non-structural protein 5BDelta55 (NS5BDelta55) over NS5BDelta55 harboring a serine-to-threonine substitution at residue 282 (NS5BDelta55S282T, IC50s = 0.07 and 25 µM, respectively). Lamevudine selectively inhibits replication of...
| Schlagworte: | 7-Deaza-2'-C-methyladenosine, MK-0608, 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Anwendung: | Antiviral |
| CAS | 443642-29-3 |
| MW: | 280.3 D |
ab 127,00 €
Tegobuvir
Artikelnummer: TGM-T17029-100mg
Description: Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor. Target: HCV Protease. Smiles: Fc1ccccc1-c1nc2ccn(Cc3ccc(nn3)-c3ccc(cc3C(F)(F)F)C(F)(F)F)cc2n1
| Schlagworte: | GS-9190, GS 333126 |
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 1000787-75-6 |
| MW: | 517.4 D |
ab 76,00 €
Taribavirin hydrochloride
Artikelnummer: TGM-T16992-100mg
Description: Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor designed to concentrate within the liver to target HCV-infected hepatocytes, while minimizing distribution within red blood cells and the development of hemolytic anemia [2]. Target: Others. Smiles:...
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 40372-00-7 |
| MW: | 279.68 D |
ab 725,00 €
Balapiravir
Artikelnummer: TGM-T14493-2mg
Description: Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safety reasons in 28-36% of patients (most often for lymphopenia) and the percentage of...
| Schlagworte: | Ro 4588161, R1626 |
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 690270-29-2 |
| MW: | 494.5 D |
105,00 €
Filibuvir
Artikelnummer: TGM-T15282-10mg
Description: Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM. Target: DNA/RNA Synthesis, HCV Protease. Smiles: CCc1cc(CC[C@@]2(CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)C2CCCC2)cc(CC)n1....
| Schlagworte: | PF-00868554 |
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 877130-28-4 |
| MW: | 503.64 D |
ab 37,00 €
MK-0608
Artikelnummer: TGM-T16088-100mg
Description: MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 µM and EC90=1.3 µM in the subgenomic-replicon assay). Target: HCV Protease. Smiles: C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc12. References: Carroll SS, et al. Robust antiviral efficacy upon administration of a...
| Anwendung: | Antiviral |
| CAS | 443642-29-3 |
| MW: | 280.28 D |
ab 70,00 €
Mericitabine
Artikelnummer: TGM-T16710-100mg
Description: Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. Target: HCV Protease. Smiles: CC(C)C(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@](C)(F)[C@@H]1OC(=O)C(C)C. References: Le Pogam S, et al....
| Schlagworte: | R-7128, RG 7128, PSI 6130 diisobutyrate |
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 940908-79-2 |
| MW: | 399.41 D |
ab 43,00 €
Setrobuvir
Artikelnummer: TGM-T28762-100mg
Description: Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp. Target: HCV Protease,...
| Schlagworte: | ANA-598, RG7790, RO-5466731, ANA598, RG-7790 |
| Anwendung: | Targets Hepatitis C virus RNA-dependent RNA polymerase [EC:2.7.7.48] (NS5B) |
| CAS | 1071517-39-9 |
| MW: | 560.62 D |
ab 227,00 €