MitoBloCK-10

A mitochondrial protein import inhibitor, inhibits the import of cytochrome c1 into the mitochondrial intermembrane space in yeast cells at 100 µM, inhibits migration and invasion of, and induces apoptosis and cell cycle arrest at the G1 phase in, primary human bladder cancer cells at 25 µM, induces mitochondrial depolarization, decreases ATP levels, and increases ROS in primary human bladder cancer cells, decreases tumor volume in a PDX mouse model of bladder cancer at 20 mg/kg every other day, intravitreal administration reduces SOD activity and increases TBARS levels and acellular capillary numbers in mouse retina at 0.25 nM/eye, induces dorsal curvature and cardiac apoptosis in zebrafish embryos at 10 µM. Formulation: A solid. InChI: InChI=1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17). InChIKey: QDYQZMWFIYLMNX-UHFFFAOYSA-N. SMILES: O=C(C1=CC(F)=CC=C1)NN=CC2=CC=C([N+]([O-])=O)S2