Metoprolol (succinate)

Metoprolol is a beta1-adrenergic receptor (beta1-AR) antagonist (Ki = 47 nM in CHO cells expressing the human receptor). It is selective for beta1- over beta2- and beta3-ARs (Kis = 2,730 and >10,000 nM, respectively, in CHO cells expressing the human receptors). Metoprolol (4.7 µM) reduces GTP-induced adenylyl cyclase (AC) activity in CHO cells expressing beta1- and beta2-ARs. It reduces pulse rate in isolated rat atria in a concentration-dependent manner. Metoprolol (10 mg/kg) reduces increased heart rate and mean arterial pressure (MAP) in a rat model of systolic hypertension induced by a fructose-rich diet. Formulations containing metoprolol have been used in the treatment of exercised-induced hypertension, angina, and tachycardia. This product is also available as an analytical reference standard (Cay-21165).Formal Name: butanedioic acid, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2). CAS Number: 98418-47-4. Molecular Formula: C15H25NO3 . 1/2C4H6O4. Formula Weight: 326.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 224, 276 nm. SMILES: COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.O=C(CCC(O)=O)O. InChi Code: InChI=1S/C15H25NO3.C4H6O4/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3,5-3(6)1-2-4(7)8/h4-7,12,14,16-17H,8-11H2,1-3H3,1-2H2,(H,5,6)(H,7,8). InChi Key: ZBOQQGAVXCUYJM-UHFFFAOYSA-N.