Metoprolol-d6 (tartrate)

Metoprolol-d6 is intended for use as an internal standard for the quantification of metoprolol (Cay-15429) by GC- or LC-MS. Metoprolol is a beta1-adrenergic receptor (beta1-AR) antagonist (Ki = 47 nM in CHO cells expressing the human receptor). It is selective for beta1- over beta2- and beta3-ARs (Kis = 2,730 and >10,000 nM, respectively, in CHO cells expressing the human receptors). Metoprolol (4.7 µM) reduces GTP-induced adenylyl cyclase (AC) activity in CHO cells expressing beta1- and beta2-ARs. It reduces pulse rate in isolated rat atria in a concentration-dependent manner. Metoprolol (10 mg/kg) reduces increased heart rate and mean arterial pressure (MAP) in a rat model of systolic hypertension induced by a fructose-rich diet. Formulations containing metoprolol have been used in the treatment of exercised-induced hypertension, angina, and tachycardia.Formal Name: 1-[4-(2-methoxyethyl)phenoxy]-3-[[1-(methyl-d3)ethyl-2,2,2-d3]amino]-2-propanol, 2R,3R-dihydroxybutanedioate (2:1). Molecular Formula: C15H19D6NO3 . 1/2C4H6O6. Formula Weight: 348.5. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble, Water: soluble. SMILES: COCCC1=CC=C(OCC(O)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.COCCC2=CC=C(OCC(O)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C2. InChi Code: InChI=1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3,5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3,1-2,5-6H,(H,7,8)(H,9,10)/t,,1-,2-/m..1/s1/i2*1D3,2D3,. InChi Key: YGULWPYYGQCFMP-MFXGARSWSA-N.