Methapyrilene (hydrochloride)

Methapyrilene is a histamine H1 receptor antagonist (Ki = 4.5 nM) and non-genotoxic carcinogen. Dietary administration of methapyrilene (0.1%) induces liver tumors in rats, with greater than 50% of rats incurring distant metastases. It decreases the acetylation of histone 3 lysine 9 (H3K9) and H3K56, as well as the di- and trimethylation of H3K4 and H4K20, respectively, in rat liver when administered at 40 mg/kg per day for six weeks. Methapyrilene also increases 4-hydroxy nonenal (4-NHE) protein adducts in rat liver. Formulations containing methapyrilene were previously used as sleep aids.Formal Name: N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-1,2-ethanediamine, monohydrochloride. CAS Number: 135-23-9. Molecular Formula: C14H19N3S . HCl. Formula Weight: 297.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 241 nm. SMILES: CN(C)CCN(CC1=CC=CS1)C2=NC=CC=C2.Cl. InChi Code: InChI=1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14,/h3-8,11H,9-10,12H2,1-2H3,1H. InChi Key: BONORRGKLJBGRV-UHFFFAOYSA-N.