Metformin

Description: Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research. Target: AMPK, Autophagy, Mitophagy. Smiles: CN(C)C(=N)NC(N)=N. References: Erices R, et al. Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells. Reprod Sci. 2013 Dec,20(12):1433-46.