Zu "K07198" wurden 251 Artikel gefunden!
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Metformin (hydrochloride)
Artikelnummer: Cay13118-5
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
| Schlagworte: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Anwendung: | AMPK activator |
| CAS | 1115-70-4 |
| MW: | 165.6 D |
ab 45,00 €
NEU
Anti-AMPK alpha 1 / PRKAA1
Artikelnummer: NSJ-F50188-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act...
| Schlagworte: | Anti-PRKAA1, Anti-Tau-protein kinase PRKAA1, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €
NEU
Anti-AMPK alpha 2 / PRKAA2
Artikelnummer: NSJ-F50381-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular...
| Schlagworte: | Anti-PRKAA2, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase kinase, Anti-5'-AMP-activated... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
NEU
Anti-AMPK alpha 1 / PRKAA1, clone 167CT22.1.6
Artikelnummer: NSJ-F40234-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. AMPK alpha is the catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and...
| Schlagworte: | Anti-PRKAA1, Anti-Tau-protein kinase PRKAA1, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase... |
| Anwendung: | WB, ELISA |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 361,00 €
NEU
Anti-AMPK alpha 2 / PRKAA2
Artikelnummer: NSJ-F50190-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). It acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36'...
| Schlagworte: | Anti-PRKAA2, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase kinase, Anti-5'-AMP-activated... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €
Anti-Recombinant Phospho-AMPK alpha1, 2 (Thr183, Thr172),...
Artikelnummer: E-AN301152L.100
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular...
| Schlagworte: | Anti-PRKAA1, Anti-Tau-protein kinase PRKAA1, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant AMPK alpha 1+AMPK alpha 2, clone A578
Artikelnummer: E-AN301866L.100
AMPK alpha is the catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits...
| Schlagworte: | Anti-PRKAA1, Anti-Tau-protein kinase PRKAA1, Anti-Acetyl-CoA carboxylase kinase, Anti-Hydroxymethylglutaryl-CoA reductase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
AICAR
Artikelnummer: Cay10010241-50
AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...
| Schlagworte: | Acadesine, AICA-Riboside, NSC 105823, 5-amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| Anwendung: | AMPK activator |
| CAS | 2627-69-2 |
| MW: | 258.2 D |
ab 76,00 €
Dorsomorphin
Artikelnummer: Cay11967-10
Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3),...
| Schlagworte: | BML-275, Compound C, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine |
| Anwendung: | AMPK inhibitor, autophagy inducer |
| CAS | 866405-64-3 |
| MW: | 399.5 D |
ab 89,00 €
A-769662
Artikelnummer: Cay11900-5
A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates beta1 subunit-containing AMPK heterotrimers, and its effects are independent...
| Schlagworte: | 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Anwendung: | AMPK activator |
| CAS | 844499-71-4 |
| MW: | 360.4 D |
ab 107,00 €
YW2065
Artikelnummer: Cay42959-10
YW2065 is an inhibitor of Wnt/beta-catenin signaling and an activator of AMP-activated protein kinase (AMPK). It induces degradation of beta-catenin and increases the levels of Axin1 and phosphorylated AMPK and acetyl-CoA carboxylase (ACC), which is a downstream substrate of AMPK, in SW620 colorectal cancer cells...
| Schlagworte: | 1-(2-bromophenyl)-5-methyl-N-2-quinolinyl-1H-pyrazole-4-carboxamide |
| Anwendung: | Wnt/beta-catenin inhibitor, AMPK activator |
| CAS | 2131223-85-1 |
| MW: | 407.27 D |
ab 162,00 €
Cordycepin
Artikelnummer: Cay14426-10
Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities. Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis. It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells....
| Schlagworte: | 3'-Deoxyadenosine, NSC 401022, NSC 63984, 3'-deoxy-adenosine |
| Anwendung: | Nucleoside analog, polyadenylation inhibitor |
| CAS | 73-03-0 |
| MW: | 251.2 D |
ab 54,00 €