Metaxalone

Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-alpha, IL-6, and prostaglandin E2 (PGE2, Cay-14010) in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.Formal Name: 5-[(3,5-dimethylphenoxy)methyl]-2-oxazolidinone. CAS Number: 1665-48-1. Synonyms: AHR 438, NSC 170959. Molecular Formula: C12H15NO3. Formula Weight: 221.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. SMILES: CC1=CC(OCC2OC(NC2)=O)=CC(C)=C1. InChi Code: InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14). InChi Key: IMWZZHHPURKASS-UHFFFAOYSA-N.