Mepyramine (maleate)

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.Formal Name: N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-1,2-ethanediamine, 2Z-butenedioate. CAS Number: 59-33-6. Synonyms: NSC 3604, Pyrilamine. Molecular Formula: C17H23N3O . C4H4O4. Formula Weight: 401.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 245, 306 nm. SMILES: COC(C=C1)=CC=C1CN(CCN(C)C)C2=NC=CC=C2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15,5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: JXYWFNAQESKDNC-BTJKTKAUSA-N.