Menaquinone 4-d7

Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 (Cay-18423) by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain. It is formed primarily via conversion of vitamin K1 (Cay-21051) in vivo and accumulates in various tissues, including the brain. MK-4 halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner. It also inhibits IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and the transcriptional activity of NF-kappaB. Vitamin K2 may have a role in bone metabolism.Formal Name: 2-(methyl-d3)-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione-5,6,7,8-d4. CAS Number: 1233937-25-1. Synonyms: MK-4-d7, Vitamin K2(20)-d7. Molecular Formula: C31H33D7O2. Formula Weight: 451.7. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), An oil. Solubility: Chloroform: Slightly Soluble. SMILES: [2H]C1=C2C(C(C(C([2H])([2H])[2H])=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C2=O)=O)=C([2H])C([2H])=C1[2H]. InChi Code: InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+/i6D3,7D,8D,18D,19D. InChi Key: DKHGMERMDICWDU-CKBRGKTGSA-N.