MEK Inhibitor II

MEK inhibitor II is an inhibitor of MEK1 (IC50 = 0.38 µM in a cell-free assay). It is selective for MEK1 over ERK1 and Raf1 (IC50s = 82.9 and 34.5 µM, respectively). It is also active against T. cruzi (IC50 = 2.77 µM). SMILES: O=C1C(Cl)=C(N2C(CCC2=O)=O)C(C3=C1C=CC=C3)=O. InChi Code: InChI=1S/C14H8ClNO4/c15-11-12(16-9(17)5-6-10(16)18)14(20)8-4-2-1-3-7(8)13(11)19/h1-4H,5-6H2. InChi Key: GYQSWJNGTWVFOL-UHFFFAOYSA-N