Zu "K04368" wurden 254 Artikel gefunden!
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NEU
Tunlametinib
Artikelnummer: Cay45050-1
A MEK1 inhibitor, selective for MEK1 over a panel of kinases panel at 10 µM, selectively reduces proliferation in a panel of cancer cell lines expressing mutant K-Ras or B-RAF (IC50s = 0.67-59.89 nM) over H1975 cells expressing wild-type K-Ras and B-Raf (IC50 = >1,000 nM), inhibits ERK phosphorylation in A375 cells...
| Schlagworte: | HL 085, 4-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-6-benzothiazolecarboxamide |
| Anwendung: | MEK1 inhibitor |
| CAS | 1801756-06-8 |
| MW: | 491.25 D |
ab 53,00 €
Anti-Recombinant MEK1/2, clone 9A7
Artikelnummer: E-AN300922L.100
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies...
| Schlagworte: | Anti-MAP2K1, Anti-MAPK/ERK kinase 1, Anti-ERK activator kinase 1, Anti-Dual specificity mitogen-activated protein kinase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Recombinant MEK1, clone 7A8
Artikelnummer: E-AN300935L.100
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies...
| Schlagworte: | Anti-MAP2K1, Anti-MAPK/ERK kinase 1, Anti-ERK activator kinase 1, Anti-Dual specificity mitogen-activated protein kinase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-MAP2K1 / Mitogen-activated protein kinase kinase 1
Artikelnummer: NSJ-FY12634
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MAP2K1 antibody detects Mitogen-activated protein kinase kinase 1, a dual-specificity protein kinase that functions as a central component of the MAPK/ERK signaling pathway. MAP2K1, also known as MEK1, phosphorylates and activates ERK1 and...
| Schlagworte: | Anti-MAP2K1, Anti-MAPK/ERK kinase 1, Anti-ERK activator kinase 1, Anti-Dual specificity mitogen-activated protein kinase... |
| Anwendung: | ELISA, FC, IF, IHC, ICC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Trametinib
Artikelnummer: Cay16292-25
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...
| Schlagworte: | GSK1120212, JTP-74057,... |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.4 D |
ab 102,00 €
U-0126
Artikelnummer: Cay70970-1
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3,...
| Schlagworte: | 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile |
| Anwendung: | MEK inhibitor |
| CAS | 109511-58-2 |
| MW: | 380.5 D |
ab 67,00 €
SB203580
Artikelnummer: AG-CR1-0030-M005
Cell permeable, specific p38 MAP kinase inhibitor, Binds to the ATP binding site of p38 MAP kinase, T cell proliferation inhibitor, IL-2 production inhibitor, SAPK/JNK inhibitor, COX-1 and -2 inhibitor, Raf-1 activator, Apoptosis enhancer, Antiproliferative, PDK1 inhibitor, Anti-inflammatory, Review.
| Schlagworte: | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| Anwendung: | p38 MAP kinase inhibitor |
| CAS | 152121-47-6 |
| MW: | 377,4 D |
ab 39,00 €
PD 98059
Artikelnummer: Cay10006726-1
PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC50 value of 50 µM. PD 98059 also phosphorylates and activates...
| Schlagworte: | NSC 679828, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Anwendung: | MAPK inhibitor |
| CAS | 167869-21-8 |
| MW: | 267.3 D |
ab 38,00 €
AZD 6244
Artikelnummer: Cay11599-10
MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of...
| Schlagworte: | ARRY-142886, CL 1,040, NSC 741O78, Selumetinib,... |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 606143-52-6 |
| MW: | 457.7 D |
ab 49,00 €
PD 0325901
Artikelnummer: Cay13034-10
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...
| Schlagworte: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Anwendung: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482.2 D |
ab 73,00 €
Binimetinib
Artikelnummer: Cay16996-5
Binimetinib is a MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively). It is selective for MEK1/2 over a panel of RAF/MEK/ERK pathway kinases at 10 µM. Binimetinib reduces cell growth in HT-29, COLO 205, and LoVo colorectal cancer cell lines (IC50s = 0.48, 0.52, and 2.2 nM, respectively). It reduces tumor...
| Schlagworte: | ARRY-438162, MEK162, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 606143-89-9 |
| MW: | 441.2 D |
ab 85,00 €
CI-1040
Artikelnummer: Cay11580-5
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50...
| Schlagworte: | PD 184352, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
| CAS | 212631-79-3 |
| MW: | 478.7 D |
ab 122,00 €