MEG (sulfate)

MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M-1s-1 at 37°C. MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.Formal Name: (2-mercaptoethyl)-guanidine sulfate. CAS Number: 3979-00-8. Molecular Formula: [C3H9N3S]2 . H2SO4. Formula Weight: 336.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (7.2): 10 mg/ml. SMILES: N/C(N([H])CCS)=N/[H].O=S(O)(O)=O.