Mebendazole

Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic. It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole reduces container attachment, a measure of viability, by G. duodenalis with a half-maximal inhibition of binding (IB50) value of 190 nM. It reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC50s = 300 and 320 µM, respectively) and induces apoptosis and poly(ADP-ribose) polymerase (PARP) cleavage in SK-MEL-19 and M14 cells, but not melanocytes, when used at a concentration of 1 µM. It decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner. In vivo, mebendazole (800 µg/animal every other day) decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model. Mebendazole (8.8 mg/kg) eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies. Formulations containing mebendazole have been used in the treatment of helminth gastrointestinal infections.Formal Name: N-(6-benzoyl-1H-benzimidazol-2-yl)-carbamic acid, methyl ester. CAS Number: 31431-39-7. Synonyms: NSC 184849, R 17635. Molecular Formula: C16H13N3O3. Formula Weight: 295.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: to 10 mM. lambdamax: 209, 246, 310 nm. SMILES: O=C(C1=CC=C(NC(NC(OC)=O)=N2)C2=C1)C3=CC=CC=C3. InChi Code: InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21). InChi Key: OPXLLQIJSORQAM-UHFFFAOYSA-N.