MDL 800

MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50 = 23.3 µM) in, and reduces proliferation of, BEL-7405 hepatocellular carcinoma (HCC) cells (EC50 = 90.4 µM). MDL 800 (0.1-5 µM) inhibits TNF-alpha release induced by oxygen and glucose deprivation (OGD) in primary mouse microglia. In vivo, MDL 800 (50, 100, and 150 mg/kg) reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model.Formal Name: 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-benzoic acid, methyl ester. CAS Number: 2275619-53-7. Molecular Formula: C21H16BrCl2FN2O6S2. Formula Weight: 626.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml. SMILES: CC1=C(NS(C2=C(C(OC)=O)C=C(NS(C3=CC(Cl)=CC(Cl)=C3)(=O)=O)C=C2)(=O)=O)C=C(Br)C(F)=C1. InChi Code: InChI=1S/C21H16BrCl2FN2O6S2/c1-11-5-18(25)17(22)10-19(11)27-35(31,32)20-4-3-14(9-16(20)21(28)33-2)26-34(29,30)15-7-12(23)6-13(24)8-15/h3-10,26-27H,1-2H3. InChi Key: FKFQBYBODAKGOA-UHFFFAOYSA-N.