Mdivi 1

Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1, IC50 = ~1-10 µM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 µM. Mdivi 1 (50 µM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine (Cay-81590) in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 µM, respectively. Mdivi 1 (1 µM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.Formal Name: 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone. CAS Number: 338967-87-6. Synonyms: Mitochondrial Division Inhibitor 1. Molecular Formula: C15H10Cl2N2O2S. Formula Weight: 353.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml. lambdamax: 223, 295 nm. SMILES: SC(N1C2=C(Cl)C=C(Cl)C(OC)=C2)=NC3=CC=CC=C3C1=O. InChi Code: InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22). InChi Key: NZJKEVWTYMOYOR-UHFFFAOYSA-N.