Maytansinol

Maytansinol is an ansa macrolide originally isolated from P. verrucose that has antimitotic and anticancer activities. It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively. Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).Formal Name: 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-maytansine. CAS Number: 57103-68-1. Synonyms: Ansamitocin P-0, Antibiotic C-15003P0, NSC 239386. Molecular Formula: C28H37ClN2O8. Formula Weight: 565.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): Partially soluble. lambdamax: 232, 244, 253 nm. SMILES: ClC1=C(N2C)C=C(C/C(C)=C/C=C/[C@@H](OC)[C@]3(O)NC(O[C@@]([C@@H](C)[C@@](O4)([H])[C@]4(C)[C@@H](O)CC2=O)([H])C3)=O)C=C1OC. InChi Code: InChI=1S/C28H37ClN2O8/c1-15-8-7-9-22(37-6)28(35)14-20(38-26(34)30-28)16(2)25-27(3,39-25)21(32)13-23(33)31(4)18-11-17(10-15)12-19(36-5)24(18)29/h7-9,11-12,16,20-22,25,32,35H,10,13-14H2,1-6H3,(H,30,34)/b9-7+,15-8+/t16-,20+,21+,22-,25+,27+,28+/m1/s1. InChi Key: QWPXBEHQFHACTK-RZKXNLMUSA-N. Origin: Synthetic.