Martinostat

An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both). Formulation: A solid. InChI: InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+/t18-,19+,20-,22?. InChIKey: WNIDBXBLQFPAJA-FQRVRAMHSA-N. SMILES: CN(CC(C=C1)=CC=C1/C=C/C(NO)=O)CC2(C[C@@H](C3)C4)C[C@@H]4C[C@@H]3C2