LY2409881

LY2409881 is a selective inhibitor of IkappaB kinase beta (IKK2, IC50 = 30 nM). It inhibits IKK1 and other common kinases at >10-fold higher concentrations. LY2409881 has been shown to suppress constitutively activated NF-kappaB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.Formal Name: 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-benzo[b]thiophene-4-carboxamide, trihydrochloride. CAS Number: 946518-60-1. Molecular Formula: C24H29ClN6OS . 3HCl. Formula Weight: 594.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml*, Ethanol: .25 mg/ml*. lambdamax: 214, 236, 315 nm. SMILES: O=C(NC1CC1)C2=C(C=C(C3=C(Cl)C=NC(NCCCN4CCN(C)CC4)=N3)S5)C5=CC=C2.Cl.Cl.Cl. InChi Code: InChI=1S/C24H29ClN6OS.3ClH/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16,,,/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29),3*1H. InChi Key: IEXCRLAGBWKVPW-UHFFFAOYSA-N.