LX2343

LX2343 is an inhibitor of beta-site amyloid protein cleaving enzyme 1 (BACE1/beta-secretase, IC50 = 11.43 µM) and PI3K (IC50 = 15.99 µM). It inhibits accumulation of Abeta (1-40) (Abeta40) and Abeta42 induced by streptozotocin (STZ, Cay-13104) in both HEK293-APPSW and CHO-APP cells, which express mutant and wild-type amyloid precursor protein (APP), respectively, in a concentration-dependent manner. It also inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as soluble APPbeta (sAPPbeta) protein levels. LX2343 (10 mg/kg per day) reduces levels of Abeta40 and Abeta42, as well as thioflavine S staining, in the cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer's disease. It also reduces cortical levels of PI3K, Akt, and mTOR phosphorylation and accumulation of the autophagy substrate p62, indicating increased autophagy. LX2343 (10 mg/kg per day) decreases path length and escape latency time in the Morris water maze in APP/PS1 mice.Formal Name: N-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-acetamide. CAS Number: 333745-53-2. Molecular Formula: C22H19ClN2O6S. Formula Weight: 474.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 33 mg/ml, DMSO: 25 mg/ml, Ethanol: Partially soluble. lambdamax: 293 nm. SMILES: O=S(C1=CC=CC=C1)(N(C2=CC(Cl)=CC=C2OC)CC(NC3=CC=C(OCO4)C4=C3)=O)=O. InChi Code: InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26). InChi Key: ZGYSGIYKAVUVOR-UHFFFAOYSA-N.