Luotonin A

Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine. It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 µg/ml). Luotonin A is structurally similar to the alkaloid camptothecin (Cay-11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 µM). Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure. Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 µM for each) in human liver microsomes.Formal Name: quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one. CAS Number: 205989-12-4. Molecular Formula: C18H11N3O. Formula Weight: 285.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform:Methanol (1:1): 2 mg/ml*, DMF: 3 mg/ml, DMSO: 3 mg/ml. lambdamax: 213, 247, 326, 341, 357 nm. SMILES: O=C1N2C(C(N=C(C=CC=C3)C3=C4)=C4C2)=NC5=CC=CC=C51. InChi Code: InChI=1S/C18H11N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(10-21(17)18)9-11-5-1-3-7-14(11)19-16/h1-9H,10H2. InChi Key: LUMDXNLBIYLTER-UHFFFAOYSA-N.