LP-935509

Description: LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM). Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1). Smiles: COc1ncccc1-c1cnn2ccc(nc12)N1CCN(CC1)C(=O)OC(C)C. References: Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep,358(3):371-86.