Loxoribine

Description: Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities. Target: TLR, Influenza Virus. Smiles: Nc1nc(=O)c2n(CC=C)c(=O)n(C3OC(CO)C(O)C3O)c2[nH]1. References: Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov,33(11):2987-97.