Loxoribine

Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 µM, respectively). Loxoribine (250 µM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs). Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-gamma secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.Formal Name: 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-guanosine. CAS Number: 121288-39-9. Synonyms: 7-Allyl-8-Oxoguanosine, RWJ 21757. Molecular Formula: C13H17N5O6. Formula Weight: 339.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 20 mg/mL. lambdamax: 251, 299 nm. SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N(CC=C)C3=C2N=C(N)NC3=O)=O)O1. InChi Code: InChI=1S/C13H17N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8(21)7(20)5(4-19)24-11/h2,5,7-8,11,19-21H,1,3-4H2,(H3,14,15,16,22)/t5-,7-,8-,11-/m1/s1. InChi Key: VDCRFBBZFHHYGT-IOSLPCCCSA-N.