Loxapine (succinate)

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and alpha1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and alpha1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.Formal Name: butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine. CAS Number: 27833-64-3. Synonyms: CL 71,563. Molecular Formula: C18H18ClN3O . C4H6O4. Formula Weight: 445.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: 5 mg/ml. lambdamax: 209, 251, 297, 323 nm. SMILES: ClC1=CC2=C(C=C1)OC3=C(C=CC=C3)N=C2N4CCN(C)CC4.OC(CCC(O)=O)=O. InChi Code: InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18,5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3,1-2H2,(H,5,6)(H,7,8). InChi Key: YQZBAXDVDZTKEQ-UHFFFAOYSA-N.