Lovastatin

Statin compound, potent competitive HMG-CoA reductase inhibitor, anti-hypercholesterolemic agent, Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids, inhibits the isoprenylation of Ras and Rho family GTPases, causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines, smooth muscle cell proliferation inhibitor, apoptosis inducer, anticancer compound, anti-adhesive, immunomodulatory and anti-inflammatory compound, stimulates bone formation, increases cellular resistance to anticancer agents such as doxorubicin and etoposide (Prod. No. AG-CR1-3572), suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection, anti-hypertensive agent, suppresses TNF-induced NF-kappaB activation, modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest)