Lorundrostat

Lorundrostat is an inhibitor of aldosterone synthase, also known as cytochrome P450 (CYP) 11B2 (CYP11B2, IC50 = 1.27 nM). It is selective for aldosterone synthase over CYP11B1 (IC50 = 475 nM). SMILES CC1=CC=C(C2=NC(N3CCN(CC(N[C@@H]4CC[C@H](CC4)NC(C)=O)=O)CC3)=NN=C2)C=C1 InChi Code InChI=1S/C24H33N7O2/c1-17-3-5-19(6-4-17)22-15-25-29-24(28-22)31-13-11-30(12-14-31)16-23(33)27-21-9-7-20(8-10-21)26-18(2)32/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,26,32)(H,27,33)/t20-,21- InChi Key YHGVDZULVMINCJ-MEMLXQNLSA-N