Zu "K07433" wurden 31 Artikel gefunden!
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Lorundrostat
Artikelnummer: Cay43548-1
Lorundrostat is an inhibitor of aldosterone synthase, also known as cytochrome P450 (CYP) 11B2 (CYP11B2, IC50 = 1.27 nM). It is selective for aldosterone synthase over CYP11B1 (IC50 = 475 nM). SMILES CC1=CC=C(C2=NC(N3CCN(CC(N[C@@H]4CC[C@H](CC4)NC(C)=O)=O)CC3)=NN=C2)C=C1 InChi Code...
| Schlagworte: | MLS-101, MT-4129, N-[trans-4-(acetylamino)cyclohexyl]-4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]-1-piperazineacetamide |
| Anwendung: | Aldosterone synthase inhibitor |
| CAS | 1820940-17-7 |
| MW: | 451.58 D |
ab 53,00 €
Baxdrostat
Artikelnummer: TGM-T61373-1mg
Description: Baxdrostat is an aldosterone synthase inhibitor. Target: Glucocorticoid Receptor, Others. Smiles: CCC(=O)N[C@@H]1CCCc2c1cncc2-c1ccc2N(C)C(=O)CCc2c1. References: Forzano I, et al. The selective aldosterone synthase inhibitor Baxdrostat significantly lowers blood pressure in patients with resistant...
| Anwendung: | Targets steroid 11beta-monooxygenase / corticosterone 18-monooxygenase (CYP11B2) |
| CAS | 1428652-17-8 |
| MW: | 363.45 D |
ab 67,00 €
Anti-CYP11B2
Artikelnummer: E-AB-17738.120
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has...
| Schlagworte: | Anti-ALDOS, Anti-CYPXIB2, Anti-Cytochrome P-450C18, Anti-Aldosterone synthase, Anti-Cytochrome P-450Aldo, Anti-Steroid... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Osilodrostat
Artikelnummer: Cay33928-10
Osilodrostat is an inhibitor of aldosterone synthase (IC50 = 0.7 nM for the recombinant human enzyme). It is selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM). Osilodrostat inhibits increases in plasma aldosterone levels induced by angiotensin II or adrenocorticotropic hormone...
| Schlagworte: | LCI699, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile |
| Anwendung: | Aldosterone synthase inhibitor |
| CAS | 928134-65-0 |
| MW: | 227.2 D |
ab 130,00 €
Anti-CYP11B2
Artikelnummer: ATA-HPA049171.100
Protein function: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21- hydroxyprogesterone, namely 11-beta hydroxylation...
| Schlagworte: | Anti-ALDOS, Anti-CYPXIB2, Anti-Cytochrome P-450C18, Anti-Cytochrome P-450Aldo, Anti-Aldosterone synthase, Anti-Steroid... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-CYP11B2
Artikelnummer: ATA-HPA057752.100
Protein function: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21- hydroxyprogesterone, namely 11-beta hydroxylation...
| Schlagworte: | Anti-ALDOS, Anti-CYPXIB2, Anti-Cytochrome P-450C18, Anti-Cytochrome P-450Aldo, Anti-Aldosterone synthase, Anti-Steroid... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Human ALDOS (Aldosterone Synthase) ELISA Kit
Artikelnummer: ELK-ELK5606.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ALDOS. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ALDOS. Next,...
| Schlagworte: | ALDOS, CYPXIB2, Cytochrome P-450C18, Cytochrome P-450Aldo, Aldosterone synthase, Steroid 18-hydroxylase,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €
Cytochrome P450 11B2, mitochondrial (CYP11B2), human,...
Artikelnummer: CSB-EP006391HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 25-503aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: GTRAARAPRT VLPFEAMPQH PGNRWLRLLQ IWREQGYEHL HLEMHQTFQE LGPIFRYNLG GPRMVCVMLP EDVEKLQQVD SLHPCRMILE PWVAYRQHRG HKCGVFLLNG...
| Schlagworte: | ALDOS, CYPXIB2, Cytochrome P-450C18, Aldosterone synthase, Cytochrome P-450Aldo, Steroid 18-hydroxylase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 71 kD |
ab 292,00 €
Cytochrome P450 11B2, mitochondrial (CYP11B2), human,...
Artikelnummer: CSB-YP006391HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 25-503aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GTRAARAPRT VLPFEAMPQH PGNRWLRLLQ IWREQGYEHL HLEMHQTFQE LGPIFRYNLG GPRMVCVMLP EDVEKLQQVD SLHPCRMILE PWVAYRQHRG HKCGVFLLNG PEWRFNRLRL...
| Schlagworte: | ALDOS, CYPXIB2, Cytochrome P-450C18, Aldosterone synthase, Cytochrome P-450Aldo, Steroid 18-hydroxylase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 57 kD |
ab 347,00 €
Osilodrostat
Artikelnummer: TGM-T4277-10mg
Description: Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11beta-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). Target: Others, Hydroxylase, Glucocorticoid Receptor. Smiles: Fc1cc(ccc1[C@H]1CCc2cncn12)C#N. References: Li L, et al. Osilodrostat (LCI699), a potent...
| Schlagworte: | LCI699 |
| Anwendung: | Targets steroid 11beta-monooxygenase / corticosterone 18-monooxygenase (CYP11B2) |
| CAS | 928134-65-0 |
| MW: | 227.24 D |
ab 32,00 €
Lorundrostat
Artikelnummer: TGM-T62747-100mg
Description: Lorundrostat (MT-4129) is an aldosterone synthase inhibitor with antihypertensive activity that lowers systolic blood pressure. Target: Others. Smiles: CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(C)cc1. References: Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for...
| Schlagworte: | MLS-101, MT 4129, MLS101, MLS 101, MT-4129, MT4129 |
| Anwendung: | Targets steroid 11beta-monooxygenase / corticosterone 18-monooxygenase (CYP11B2) |
| CAS | 1820940-17-7 |
| MW: | 451.56 D |
ab 52,00 €
CYP11B2 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-01181-100ug
Description: CYP11B2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
| Schlagworte: | Aldosterone-synthesizing enzyme, Cytochrome P-450Aldo, CYP11B2, Cytochrome P450 11B2, mitochondrial, CYPXIB2, Aldosterone... |
| MW: | 71.0 kD |
ab 266,00 €