Loratadine

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg. Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.Formal Name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester. CAS Number: 79794-75-5. Synonyms: SCH 29851. Molecular Formula: C22H23ClN2O2. Formula Weight: 382.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 247 nm. SMILES: ClC(C=C1)=CC(CCC2=C/3N=CC=C2)=C1C3=C4CCN(C(OCC)=O)CC/4. InChi Code: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3. InChi Key: JCCNYMKQOSZNPW-UHFFFAOYSA-N.