Lofexidine (hydrochloride)

Lofexidine is an alpha2-adrenergic receptor agonist (Kd = 7.6 nM for rat cerebral cortex membranes) that has transient antihypertensive effects. It is used in managing opioid withdrawal symptoms during detoxification from heroin (Cay-9001543) and methadone.Formal Name: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole, monohydrochloride. CAS Number: 21498-08-8. Molecular Formula: C11H12Cl2N2O . HCl. Formula Weight: 295.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: ClC1=CC=CC(Cl)=C1OC(C)C2=NCCN2.Cl. InChi Code: InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13,/h2-4,7H,5-6H2,1H3,(H,14,15),1H. InChi Key: DWWHMKBNNNZGHF-UHFFFAOYSA-N.