Zu "K04139" wurden 72 Artikel gefunden!
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Lofexidine hydrochloride
Artikelnummer: LKT-L5822.1
It is an alpha2-adrenergic agonist useful in the management of opioid drawer.
| Anwendung: | alpha2-adrenergic agonist |
| CAS | 21498-08-8 |
| MW: | 295,6 D |
ab 159,00 €
Spiroxatrine
Artikelnummer: Cay33415-10
Spiroxatrine is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 3 nM) and alpha2-adrenergic receptors (alpha2-ARs, Kis = 28, 1. and 1. nM for alpha2A, alpha2B, and alpha2C, respectively). It is selective for these receptors over 5-HT1D (Ki = 2 µM) and 5-HT1B at 10 µM. Spiroxatrine also induces...
| Schlagworte: | R-5188, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
| Anwendung: | 5-HT1A/alpha2-AR antagonist |
| CAS | 1054-88-2 |
| MW: | 379.45 D |
ab 122,00 €
Levonordefrin
Artikelnummer: Cay23993-10
Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Cay-16673), that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It...
| Schlagworte: | (-)-3,4-dihydroxy Norephedrine, (-)-alpha-methyl Noradrenaline, Corbadrine,... |
| Anwendung: | Vasoconstrictor, alpha2-Adrenergic receptor agonist |
| CAS | 829-74-3 |
| MW: | 183.2 D |
ab 97,00 €
Medetomidine (hydrochloride)
Artikelnummer: Cay16454-5
Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...
| Schlagworte: | Domitor(R), MPV 785, 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 86347-15-1 |
| MW: | 236.7 D |
ab 97,00 €
Yohimbine (hydrochloride)
Artikelnummer: Cay19869-1
Yohimbine is a natural alkaloid that has highest affinity for alpha2-adrenergic receptors (pKis = 8.2, 8.7, and 9.6 for human alpha2A, alpha2B, and alpha2C, respectively), with antagonist activity at these receptors. It less potently antagonizes serotonin 5-HT1 receptors (pKis = 7.3, 6.8, and 7.6 for human HT1A,...
| Schlagworte: | NIH 9689, NSC 19509, Yohimbe, 17alpha-hydroxy-yohimban-16alpha-carboxylic acid, methyl ester, monohydrochloride |
| Anwendung: | Alpha-2A/B/C adrenergic receptor antagonist |
| CAS | 65-19-0 |
| MW: | 390.9 D |
ab 51,00 €
Moxonidine
Artikelnummer: Cay25639-10
Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay). It is also an agonist of the alpha2A-adrenergic receptor (alpha2A-AR, Ki = 150 nM in a radioligand binding assay). It is selective for I1 and alpha2A-AR receptors over alpha1-, alpha2B, and alpha2C-ARs (Kis = >30,000,...
| Schlagworte: | LY326869, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine |
| Anwendung: | Centrally-acting antiadrenergic |
| CAS | 75438-57-2 |
| MW: | 241.7 D |
ab 76,00 €
Rilmenidine (hemifumarate)
Artikelnummer: Cay16988-10
Rilmenidine is an antihypertensive agent. It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as alpha2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25...
| Schlagworte: | Oxaminozoline, S 3341, N-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine, 2E-butenedioate (2:1) |
| Anwendung: | alpha2-adrenergic receptor agonist, nischarin agonist |
| CAS | 207572-68-7 |
| MW: | 238.3 D |
ab 62,00 €
Xylazine
Artikelnummer: Cay14113-10
Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...
| Schlagworte: | N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine |
| Anwendung: | alpha2 adrenergic receptor agonist |
| CAS | 7361-61-7 |
| MW: | 220.3 D |
ab 62,00 €
Rauwolscine (hydrochloride)
Artikelnummer: Cay15596-250
Rauwolscine is a natural alkaloid that acts as a selective and reversible alpha2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki...
| Schlagworte: | Isoyohimbine, NSC 407307, alpha-Yohimbine, (16beta,17alpha,20alpha)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester,... |
| Anwendung: | Selective, reversible alpha2-adrenergic receptor antagonist |
| CAS | 6211-32-1 |
| MW: | 390.9 D |
ab 58,00 €
Detomidine (hydrochloride)
Artikelnummer: Cay17853-250
Detomidine is a selective alpha2-adrenoceptor agonist (Ki = 1.62 nM) that binds to alpha1-adrenoceptors with much weaker potency (Ki = 415 nM). Formulations containing detomidine have been used as veterinary sedatives.Formal Name: 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole, monohydrochloride. CAS Number:...
| Schlagworte: | Domosedan, MPV 253AII, 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 90038-01-0 |
| MW: | 222.7 D |
ab 172,00 €
Guanabenz (hydrochloride)
Artikelnummer: Cay10851-100
Guanabenz is an alpha2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).Formal Name: 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride. CAS Number: 23113-43-1....
| Schlagworte: | Wytensin, 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride |
| Anwendung: | alpha2-adrenergic receptor agonist |
| CAS | 23113-43-1 |
| MW: | 267.5 D |
ab 70,00 €
B-HT 933 (hydrochloride)
Artikelnummer: Cay11941-1
B-HT 933 is an agonist of alpha2-adrenergic receptors (alpha2-ARs) with an EC50 value of 0.65 µM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an...
| Schlagworte: | Azepexole, Oxazoloazepin, 6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine, dihydrochloride |
| Anwendung: | alpha2-adrenoceptor agonist |
| CAS | 36067-72-8 |
| MW: | 254.2 D |
ab 51,00 €