LNT 1

LNT 1 is an inhibitor of flap endonuclease 1 (FEN1, IC50 = 0.011 µM). It is selective for FEN1 over xeroderma pigmentosum G (IC50 = 0.292 µM). LNT 1 (3 and 6 µM) enhances methyl methanesulfonate-induced DNA damage and cell death in T24 bladder cancer cells.Formal Name: 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione. CAS Number: 824983-91-7. Molecular Formula: C15H12N2O5S. Formula Weight: 332.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/mL, DMSO: 10 mg/mL, Ethanol: 4 mg/mL, PBS (pH 7.2): 0.11 mg/mL. SMILES: O=C1C2=C(N(CC3OC4=C(OC3)C=CC=C4)C(N1O)=O)C=CS2. InChi Code: InChI=1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2. InChi Key: MXQGCMQXTPTJJT-UHFFFAOYSA-N.