LH 846

LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1delta (IC50 = 290 nM). It inhibits CK1epsilon and CK1alpha at much higher concentrations (IC50s = 1.3 and 2.5 µM, respectively) but does not inhibit CK2. LH 846 has been shown to inhibit CK1delta-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.Formal Name: N-(5-chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide. CAS Number: 639052-78-1. Molecular Formula: C16H13ClN2OS. Formula Weight: 316.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/mL, DMSO: 5 mg/mL. lambdamax: 212, 233, 274, 296, 307 nm. SMILES: CC1=C(Cl)C=C(N=C(NC(CC2=CC=CC=C2)=O)S3)C3=C1. InChi Code: InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20). InChi Key: DYHAMRNAHTWYKY-UHFFFAOYSA-N.