Levomilnacipran (hydrochloride)

Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Cay-23837). It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = >10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.Formal Name: 2R-(aminomethyl)-N,N-diethyl-1S-phenyl-cyclopropanecarboxamide, monohydrochloride. CAS Number: 175131-60-9. Synonyms: (1S-cis)-Milnacipran. Molecular Formula: C15H22N2O . HCl. Formula Weight: 282.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 33 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 207 nm. SMILES: NC[C@@H]1C[C@@]1(C(N(CC)CC)=O)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12,/h5-9,13H,3-4,10-11,16H2,1-2H3,1H/t13-,15+,/m0./s1. InChi Key: XNCDYJFPRPDERF-NQQJLSKUSA-N.