Lenalidomide-Br

Description: Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36. Target: Ligand for E3 Ligase. Smiles: O=C1N(CC=2C1=CC=CC2Br)C3C(=O)NC(=O)CC3. References: Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11,36(5):498-511.e17.