Zu "K11793" wurden 133 Artikel gefunden!
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Protein cereblon (CRBN), recombinant human
Artikelnummer: CSB-MP842761HU.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 1-442aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE...
| Schlagworte: | CRBN, AD-006, Protein cereblon |
| Anwendung: | Activity not tested |
| Exprimiert in: | Mammalian cells |
| Ursprungsart: | human |
| MW: | 53.0 kD |
ab 371,00 €
EM12-SO2F
Artikelnummer: Cay41446-10
EM12-SO2F is a covalent inhibitor of cereblon (CRBN, IC50 = 0.88 nM). It inhibits the degradation of Ikaros family zinc finger protein 1 (IKZF1) induced by the thalidomide derivative lenalidomide (Cay-14643) in MOLT-4 lymphoblasts when used at a concentration of 1 µM.Formal Name:...
| Schlagworte: | 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride |
| Anwendung: | Covalent cereblon inhibitor |
| CAS | 2803819-61-4 |
| MW: | 326.3 D |
ab 103,00 €
PROTAC CRBN Degrader-1
Artikelnummer: Cay41878-1
PROTAC CRBN degrader-1 is a proteolysis-targeting chimera (PROTAC) that contains VHL ligand 1 (Cay-21591) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HeLa cells with a half-maximal degradation concentration (DC50) value of 200 nM.Formal Name:...
| Schlagworte: | PROTAC Cereblon Degrader-1, Proteolysis-targeting Chimera Cereblon Degrader-1, Proteolysis-targeting Chimera CRBN... |
| Anwendung: | CRBN degradation driving PROTAC |
| CAS | 2358775-70-7 |
| MW: | 1061.3 D |
ab 171,00 €
ARV-825
Artikelnummer: TGM-T5434-100mg
Description: ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. Target: Epigenetic Reader Domain, PROTACs. Smiles:...
| Anwendung: | Protac(R) reagent |
| CAS | 1818885-28-7 |
| MW: | 923.43 D |
ab 60,00 €
CFT7455
Artikelnummer: TGM-T60024-10mg
Description: CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3). Target: Ligand for E3 Ligase. Smiles:...
| Schlagworte: | Cemsidomide |
| Anwendung: | Protac(R) reagent |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
ab 79,00 €
Thalidomide-O-COOH
Artikelnummer: TGM-T7753-1mL
Description: Thalidomide-O-COOH (Cereblon ligand 3) is a Thalidomide-based Cereblon ligand utilized for recruiting the CRBN protein and can be linked to a protein ligand via a linker to create PROTACs. Target: Others, Ligand for E3 Ligase. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(O)=O
| Schlagworte: | Cereblon ligand 3, E3 ligase Ligand 3, TCE35031 |
| Anwendung: | Protac(R) reagent |
| CAS | 1061605-21-7 |
| MW: | 332.27 D |
ab 30,00 €
Thalidomide 4-fluoride
Artikelnummer: TGM-T7755-500mg
Description: Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4...
| Schlagworte: | E3 ligase Ligand 4 |
| Anwendung: | Protac(R) reagent |
| CAS | 835616-60-9 |
| MW: | 276.22 D |
30,00 €
Pomalidomide-PEG4-Ph-NH2
Artikelnummer: TGM-T7756-100mg
Description: Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate that integrates a Pomalidomide-based cereblon ligand with a 4-unit PEG linker. Target: Ligand for E3 Ligase. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCO CCOC4=CC=C(N)C=C4. References: Andrew P. Crew, et al....
| Anwendung: | Protac(R) reagent |
| CAS | 1818885-63-0 |
| MW: | 540.57 D |
ab 31,00 €
Thalidomide-4-OH
Artikelnummer: TGM-T7763-500mg
Description: Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs. Target: Ligand for E3 Ligase. Smiles: OC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O. References: Marks MG, et...
| Schlagworte: | Cereblon ligand 2, E3 ligase Ligand 2 |
| Anwendung: | Protac(R) reagent |
| CAS | 5054-59-1 |
| MW: | 274.23 D |
30,00 €
Pomalidomide 4'-PEG5-amine
Artikelnummer: TGM-T83953-25mg
Target: Others. Smiles: Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCO CCOCCOCCN)C3C2=O)CC1
| Anwendung: | PEGylated cereblon (CRBN) inhibitor pomalidomide |
| CAS | 2357117-23-6 |
| MW: | 573.04 D |
397,00 €
Thalidomide-PEG4-Propargyl
Artikelnummer: TGM-T9389-100mg
Description: Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology[1]. Target: E3 Ligase Ligand-Linker Conjugate. Smiles:...
| Schlagworte: | Thalidomide-O-PEG4-Propargyl |
| Anwendung: | Protac(R) reagent |
| CAS | 2098799-77-8 |
| MW: | 488.49 D |
ab 33,00 €
Cereblon inhibitor 1
Artikelnummer: TGM-T82745-50mg
Description: Cereblon inhibitor 1 (isoindoline) serves as a modulator of the cereblon E3 ubiquitin ligase and shows promise for applications in cancer research. Target: Others. Smiles: O(CC1=C(F)C=C(CN2CCN(CC2)C3=C(F)C(Cl)=C(C#N)C=C3)C=C1)C4=C5C(C(=O)N(C5)[C@@H]6C(=O)NC(=O)CC6)=CC=C4
| Anwendung: | Cereblon inhibitor |
| CAS | 2672489-14-2 |
| MW: | 620.05 D |
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