Zu "K11793" wurden 142 Artikel gefunden!
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NEU
CRBNmidi (human, recombinant)
Artikelnummer: Cay45179-10
Source: Recombinant human N-terminal His-tagged CRBNmidi expressed in E. coli Amino acids: 41-187-GSG-249-426 MW: 39.8 kDa. SMILES: . InChi Code: . InChi Key:
| Schlagworte: | Cereblonmidi |
| Exprimiert in: | E. coli |
ab 345,00 €
Anti-CRBN / Cereblon
Artikelnummer: NSJ-FY12446
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. CRBN antibody recognizes Cereblon, a substrate receptor component of the CRL4 E3 ubiquitin ligase complex that plays a central role in targeted protein degradation. Cereblon binds to the DDB1-CUL4-ROC1 complex, recruiting specific substrates...
| Schlagworte: | Anti-CRBN, Anti-Protein cereblon, CRBN Antibody / Cereblon |
| Anwendung: | WB, ICC/IF, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
TD-106
Artikelnummer: Cay44836-10
TD-106 is a modulator of cereblon. It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0....
| Schlagworte: | 3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2,6-piperidinedione |
| Anwendung: | Cereblon modulator |
| CAS | 2250288-69-6 |
| MW: | 273.25 D |
ab 236,00 €
TD-165
Artikelnummer: Cay44837-1
TD-165 is a proteolysis-targeting chimera (PROTAC) that contains VH 032 (Cay-39982) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HEK293T cells with a half-maximal degradation concentration (DC50) value of 20. nM. TD-165 (0. µM) increases L-type voltage-gated...
| Schlagworte: | (2S,4R)-1-((2S)-2-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethyl-butanoyl)-4-... |
| Anwendung: | CRBN degradation driving PROTAC |
| CAS | 2305936-56-3 |
| MW: | 870.08 D |
ab 76,00 €
Golcadomide
Artikelnummer: Cay44114-1
Golcadomide is a cereblon (CRBN) E3 ligase modulator (CELMoD). It decreases protein levels of Ikaros family zinc finger protein 1 (IKZF1) and IFN regulatory factor 4 (IRF4) in JSC-1, BCBL-1, Daudi, and BL-41 lymphoma cells when used at a concentration of 0. µM and decreases the viability of these cells in a...
| Schlagworte: | CC-99282,... |
| Anwendung: | Cereblon modulator, CELMoD, antineoplastic, thalidomide derivative |
| CAS | 2379572-34-4 |
| MW: | 535.58 D |
ab 246,00 €
CC-885
Artikelnummer: Cay19966-1
CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines. It forms a complex with cereblon and the cell cycle regulator and translation termination factor GSPT1. The antitumour activity of CC-885 relies on cereblon-dependent ubiquitination and...
| Schlagworte: | N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea |
| Anwendung: | CRBN modulator |
| CAS | 1010100-07-8 |
| MW: | 440.9 D |
ab 134,00 €
PT-179
Artikelnummer: Cay43028-5
PT-179 is a molecular glue and ligand for the E3 ubiquitin ligase cereblon. It has been used in conjunction with the zinc finger degron SD40 to induce degradation of SD40-tagged proteins.. Solulibility: DMSO: Soluble: = 10 mg/ml: .
| Schlagworte: | 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-1H-isoindole-1,3(2H)-dione |
| Anwendung: | Molecular glue, cereblon ligand |
| CAS | 2924858-25-1 |
| MW: | 343.34 D |
ab 127,00 €
Cereblon Binding Assay Kit
Artikelnummer: BPS-79899
The Cereblon Binding Assay Kit (FP) is designed for testing and profiling of Cereblon (CRBN) inhibitors using Fluorescence Polarization. The assay is a competitive binding assay, based on the binding of fluorescently-labeled Thalidomide, a CRBN binder, to purified recombinant CRBN. CRBN is the substrate recognition...
| Schlagworte: | CRBN, AD-006, Protein cereblon |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.482,00 €
dBET1
Artikelnummer: Cay18044-1
dBET1 is a hybrid molecule that combines (+)-JQ1 (Cay-11187) and thalidomide (Cay-14610). The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition...
| Schlagworte: | (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]but... |
| Anwendung: | Cereblon-dependent BET protein degradation |
| CAS | 1799711-21-9 |
| MW: | 785.3 D |
ab 67,00 €
(±)-Thalidomide
Artikelnummer: Cay14610-100
(±)-Thalidomide is an immunomodulatory compound with diverse biological activities, including anticancer, anti-inflammatory, and teratogenic properties. It prevents polymorphonuclear leukocyte (PMN) chemotaxis when used at concentrations of 1, 10, and 100 µg/ml. (±)-Thalidomide increases IL-2-induced proliferation...
| Schlagworte: | N-Phthaloylglutamimide, NSC 527179, NSC 66847, 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Anwendung: | E3 UB ligase inhibitor |
| CAS | 50-35-1 |
| MW: | 258.2 D |
ab 85,00 €
Pomalidomide
Artikelnummer: Cay19877-1
Pomalidomide is an analog of thalidomide (Cay-14610) that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 µM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those...
| Schlagworte: | 3-amino Thalidomide, CC-4047, 4-amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Anwendung: | Immunomodulator, cereblon autoubiquitination inhibitor |
| CAS | 19171-19-8 |
| MW: | 273.2 D |
ab 49,00 €
Protein cereblon (CRBN), partial, Biotinylated, human,...
Artikelnummer: CSB-EP842761HU1-B.20
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 318-426aa. Protein Length: Partial. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged. Target Protein Sequence: CTSLCCKQCQ ETEITTKNEI FSLSLCGPMA AYVNPHGYVH ETLTVYKACN LNLIGRPSTE HSWFPGYAWT VAQCKICASH IGWKFTATKK DMSPQKFWGL TRSALLPTI....
| Schlagworte: | CRBN, AD-006, Protein cereblon, Recombinant Human Protein cereblon (CRBN), partial, Biotinylated |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 59.9 kD |
ab 439,00 €