Zu "K11793" wurden 76 Artikel gefunden!
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Mouse CRBN (Cereblon) ELISA Kit
Artikelnummer: ELK-ELK7246.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CRBN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CRBN. Next,...
| Schlagworte: | Crbn, Protein PiL, Protein cereblon |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Human CRBN (Cereblon) ELISA Kit
Artikelnummer: ELK-ELK4870.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CRBN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CRBN. Next,...
| Schlagworte: | CRBN, AD-006, Protein cereblon |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Anti-CRBN
Artikelnummer: ARG44026.50
Protein function: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and...
| Schlagworte: | Anti-CRBN, Anti-AD-006, Anti-Protein cereblon, Anti-Protein cereblon |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
544,00 €
CC-885
Artikelnummer: Cay19966-1
CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines. It forms a complex with cereblon and the cell cycle regulator and translation termination factor GSPT1. The antitumour activity of CC-885 relies on cereblon-dependent ubiquitination and...
| Schlagworte: | N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea |
| Anwendung: | CRBN modulator |
| CAS | 1010100-07-8 |
| MW: | 440.9 D |
ab 121,00 €
dBET1
Artikelnummer: Cay18044-1
dBET1 is a hybrid molecule that combines (+)-JQ1 (Cay-11187) and thalidomide (Cay-14610). The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition...
| Schlagworte: | (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]but... |
| Anwendung: | Cereblon-dependent BET protein degradation |
| CAS | 1799711-21-9 |
| MW: | 785.3 D |
ab 60,00 €
(±)-Thalidomide
Artikelnummer: Cay14610-100
(±)-Thalidomide is an immunomodulatory compound with diverse biological activities, including anticancer, anti-inflammatory, and teratogenic properties. It prevents polymorphonuclear leukocyte (PMN) chemotaxis when used at concentrations of 1, 10, and 100 µg/ml. (±)-Thalidomide increases IL-2-induced proliferation...
| Schlagworte: | N-Phthaloylglutamimide, NSC 527179, NSC 66847, 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Anwendung: | E3 UB ligase inhibitor |
| CAS | 50-35-1 |
| MW: | 258.2 D |
ab 77,00 €
Cereblon Binding Assay Kit
Artikelnummer: BPS-79899
The Cereblon Binding Assay Kit (FP) is designed for testing and profiling of Cereblon (CRBN) inhibitors using Fluorescence Polarization. The assay is a competitive binding assay, based on the binding of fluorescently-labeled Thalidomide, a CRBN binder, to purified recombinant CRBN. CRBN is the substrate recognition...
| Schlagworte: | CRBN, AD-006, Protein cereblon |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
883,00 €
Pomalidomide
Artikelnummer: Cay19877-1
Pomalidomide is an analog of thalidomide (Cay-14610) that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 µM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those...
| Schlagworte: | 3-amino Thalidomide, CC-4047, 4-amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Anwendung: | Immunomodulator, cereblon autoubiquitination inhibitor |
| CAS | 19171-19-8 |
| MW: | 273.2 D |
ab 43,00 €
Cereblon Ligand 1
Artikelnummer: Cay21589-10
Cereblon ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).Formal Name: 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetic acid. CAS Number: 1061605-21-7. Molecular Formula: C15H12N2O7. Formula Weight: 332.3. Purity: >95%....
| Schlagworte: | 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetic acid |
| Anwendung: | PROTAC synthesis building block |
| CAS | 1061605-21-7 |
| MW: | 332.3 D |
ab 109,00 €
Iberdomide
Artikelnummer: Cay22615-10
Iberdomide is a modulator of cereblon, a substrate receptor in the CRL4 ubiquitin ligase complex, that has an IC50 value of 60 nM in a competitive TR-FRET assay. In the same assay, it has a higher affinity for cereblon than the related modulators lenalidomide (Cay-14643, IC50 = 1,500 nM) and pomalidomide (Cay-19877,...
| Schlagworte: | CC-220, 3S-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione |
| Anwendung: | Cereblon modulator |
| CAS | 1323403-33-3 |
| MW: | 449.5 D |
ab 43,00 €
Azido-Thalidomide
Artikelnummer: Cay26146-50
Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies. It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the...
| Schlagworte: | N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide |
| Anwendung: | Building block, PROTAC, cereblon ligand, click chemistry |
| CAS | 2098488-36-7 |
| MW: | 428.4 D |
ab 84,00 €
Cereblon/DDB1/Cul4A/Rbx1 Complex
Artikelnummer: BPS-100329-1
Cereblon/DDB1/Cul4A/Rbx1 complex of human Cereblon (GenBank Accession No. NM_016302) a.a. 2-442(end) with N-terminal FLAG-tag and MW= 51 kDa, human DDB1 (GenBank Accession No. NM_001923), a.a. 1-1140(end) with N-terminal FLAG-tag and MW= 128 kDa, human Cul4A (GenBank Accession No. NM_003589), a.a. 2-759(end) with...
| Schlagworte: | CRBN, AD-006, Protein cereblon, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | human cells |
| Ursprungsart: | human |
| MW: | 51/128/87... kD |
ab 378,00 €