Lenacapavir

An inhibitor of HIV capsid protein-protein interactions, inhibits viral replication in HIV-1-infected primary human CD4+ T cells and macrophages (mean IC50s = 32 and 56 pM, respectively), two HIV-2 clinical isolates (mean IC50 = 885 pM), and 23 HIV-1 clinical isolates (mean IC50 = 50 pM), prevents stHIV-A19 infection in pigtail macaques at 25 mg/kg, s.c.. Formulation: A solid. InChI: InChI=1S/C39H32ClF10N7O5S2/c1-36(2,63(3,59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43,44)45)54-35(30)55-64(4,61)62)31(51-21)27(13-18-11-19(41)14-20(42)12-18)52-28(58)16-56-34-29(33(53-56)39(48,49)50)24-15-25(24)38(34,46)47/h5-8,11-12,14,24-25,27H,13,15-17H2,1-4H3,(H,52,58)(H,54,55)/t24-,25+,27-/m0/s1. InChIKey: BRYXUCLEHAUSDY-WEWMWRJBSA-N. SMILES: O=C(N[C@H](C1=C(C(C=C2)=C(N3CC(F)(F)F)C(C(NS(C)(=O)=O)=N3)=C2Cl)C=CC(C#CC(C)(C)S(C)(=O)=O)=N1)CC4=CC(F)=CC(F)=C4)CN5N=C(C(F)(F)F)C6=C5C(F)(F)[C@@]7([H])[C@]6([H])C7