Larixyl Acetate

Larixyl acetate is a diterpenoid that has been found in Larix and has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities. It inhibits the activity of TRPC6 (IC50 = 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50 = 6.83 µM), as well as over nine additional TRP channels at 10 µM. Intrathecal administration of larixyl acetate reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI).Formal Name: (alphaS,1S,4S,4aS,8aR)-4-(acetyloxy)-alpha-ethenyldecahydro-alpha,5,5,8a-tetramethyl-2-methylene-1-naphthalenepropanol. CAS Number: 4608-49-5. Synonyms: Larixol Acetate. Molecular Formula: C22H36O3. Formula Weight: 348.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Ethyl Acetate: slightly soluble. SMILES: C[C@]12[C@@](C(C)(CCC2)C)([H])[C@H](CC([C@@H]1CC[C@](C)(O)C=C)=C)OC(C)=O. InChi Code: InChI=1S/C22H36O3/c1-8-21(6,24)13-10-17-15(2)14-18(25-16(3)23)19-20(4,5)11-9-12-22(17,19)7/h8,17-19,24H,1-2,9-14H2,3-7H3/t17-,18-,19-,21+,22+/m0/s1. InChi Key: WCNCDVQMEQJFGH-TZWCSUAMSA-N. Origin: Synthetic.