Zu "K04969" wurden 42 Artikel gefunden!
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Human TRPC6-Strep full length protein-synthetic nanodisc
Artikelnummer: DIM-FLP120759.10
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not...
| Schlagworte: | TRP-6, TrpC6, Transient receptor protein 6, Short transient receptor potential channel 6 |
| Anwendung: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 106.3 kD |
ab 1.162,00 €
TRPC3/6-IN-1
Artikelnummer: TGM-T61407-10mg
Description: TRPC3/6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on...
| Anwendung: | TRPC3 / TRPC6 inhibitor |
| CAS | 736945-96-3 |
| MW: | 365.45 D |
ab 83,00 €
SAR7334 hydrochloride
Artikelnummer: TGM-T12849L-100mg
Description: SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel. Target: Others. Smiles: Cl.Cl.N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N. References: Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume...
| Anwendung: | TRPC6 blocker |
| CAS | 1333207-63-8 |
| MW: | 440.79 D |
ab 46,00 €
Anti-TRPC6
Artikelnummer: CSB-PA215862.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPC6. Antigen Species: Human
| Schlagworte: | Anti-TrpC6, Anti-TRP-6, Anti-Transient receptor protein 6, Anti-Short transient receptor potential channel 6, bZ1P14.9... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-TRPC6
Artikelnummer: CSB-PA281056.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPC6. Antigen Species: Human
| Schlagworte: | Anti-TrpC6, Anti-TRP-6, Anti-Transient receptor protein 6, Anti-Short transient receptor potential channel 6, bZ1P14.9... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Short transient receptor potential channel 6 (TRPC6),...
Artikelnummer: CSB-MP1339HU.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 543-592aa. Protein Length: Partial. Tag Info: C-terminal hFc-tagged. Target Protein Sequence: ARFMAFWHAS KAQSIIDAND TLKDLTKVTL GDNVKYYNLA RIKWDPSDPQ. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological...
| Schlagworte: | TrpC6, TRP-6, Transient receptor protein 6, Short transient receptor potential channel 6, Recombinant Human Short... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Mammalian cells |
| Ursprungsart: | human |
| MW: | 34.7 kD |
ab 606,00 €
BI-749327
Artikelnummer: Cay39672-1
BI-749327 is an inhibitor of transient receptor potential canonical 6 (TRPC6, IC50 = 13 nM for the mouse channel). It is selective for TRPC6 over TRPC3 and TRPC7 (IC50s = 1,100 and 550 nM, respectively, for the mouse channels). BI-749327 (100, 250, and 500 nM) inhibits TRPC6-mediated reporter gene expression in...
| Schlagworte: | [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-methanone |
| Anwendung: | TRPC6 inhibitor |
| CAS | 2361241-23-6 |
| MW: | 442.4 D |
ab 103,00 €
GSK1702934A
Artikelnummer: Cay34576-1
GSK1702934A is an activator of transient receptor potential canonical 3 (TRPC3) and TRPC6. It induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing the human channels (EC50s = 0.08 and 0.44 µM, respectively). GSK1702934A enhances contractility and induces...
| Schlagworte: | 1,3-dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| Anwendung: | TRPC3 / TRPC6 activator |
| CAS | 924377-85-5 |
| MW: | 395.5 D |
ab 44,00 €
SAR7334 (hydrochloride)
Artikelnummer: Cay28292-1
SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM). It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 µM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also...
| Schlagworte: | 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-benzonitrile, dihydrochloride |
| Anwendung: | TRPC6 blocker |
| CAS | 1333207-63-8 |
| MW: | 440.8 D |
ab 52,00 €
Larixyl Acetate
Artikelnummer: Cay35309-5
Larixyl acetate is a diterpenoid that has been found in Larix and has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities. It inhibits the activity of TRPC6 (IC50 = 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50 = 6.83 µM), as well as over nine additional TRP channels at 10 µM....
| Schlagworte: | Larixol Acetate,... |
| Anwendung: | Diterpenoid, TRPC6 inhibitory / analgesic agent |
| CAS | 4608-49-5 |
| MW: | 348.5 D |
ab 49,00 €
Anti-TRPC6 (Transient Receptor Potential Cation Channel...
Artikelnummer: 200-301-B59
Protein function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion,...
| Schlagworte: | Anti-TRP6, Anti-TRP-6, Anti-TRPC6, Anti-TrpC6, Anti-Transient receptor protein 6, Anti-Short transient receptor potential... |
| Anwendung: | ELISA, IHC, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, chimpanzee |
ab 180,00 €
N-(p-amylcinnamoyl) Anthranilic Acid
Artikelnummer: Cay14531-50
N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 µM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of...
| Schlagworte: | ACA, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid |
| Anwendung: | TRP channel blocker |
| CAS | 110683-10-8 |
| MW: | 337.4 D |
ab 85,00 €