Laninamivir octanoate

Laninamivir octanoate is an inhibitor of influenza neuraminidases and a prodrug form of laninamivir. It selectively inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 822, 128, and 114 nM, respectively) over the neuraminidases from influenza B Victoria and Yamagata strains (mean IC50s = >10,000 nM for both). Intranasal administration of laninamivir octanoate (0.95 µg/kg) increases survival in a mouse model of lethal influenza H1N1 infection. Formulations containing laninamivir octanoate have been used in the prevention of influenza.Formal Name: 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, 9-octanoate. CAS Number: 203120-46-1. Synonyms: CS 8958. Molecular Formula: C21H36N4O8. Formula Weight: 472.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: OC(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@]([C@@H]([C@@H](COC(CCCCCCC)=O)O)OC)([H])O1)=O. InChi Code: InChI=1S/C21H36N4O8/c1-4-5-6-7-8-9-16(28)32-11-14(27)18(31-3)19-17(24-12(2)26)13(25-21(22)23)10-15(33-19)20(29)30/h10,13-14,17-19,27H,4-9,11H2,1-3H3,(H,24,26)(H,29,30)(H4,22,23,25)/t13-,14+,17+,18+,19+/m0/s1. InChi Key: UKTIJASCFRNWCB-RMIBSVFLSA-N.