Lanicemine

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM. Compared to ketamine (Cay-11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.Formal Name: (alphaS)-phenyl-2-pyridineethanamine. CAS Number: 153322-05-5. Synonyms: AZD 6765, AR-R 15896AR. Molecular Formula: C13H14N2. Formula Weight: 198.3. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 5 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 263 nm. SMILES: N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2. InChi Code: InChI=1S/C13H14N2/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12/h1-9,13H,10,14H2/t13-/m0/s1. InChi Key: FWUQWDCOOWEXRY-ZDUSSCGKSA-N.