Lalistat 2

Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 152 nM using purified human LAL). It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Cay-10006627) and oleic acid (Cay-90260).Formal Name: 1-piperidinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester. CAS Number: 1234569-09-5. Molecular Formula: C13H20N4O2S. Formula Weight: 296.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 306 nm. SMILES: O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3. InChi Code: InChI=1S/C13H20N4O2S/c18-13(17-9-5-2-6-10-17)19-12-11(14-20-15-12)16-7-3-1-4-8-16/h1-10H2. InChi Key: PNYYVHOTXOEBEV-UHFFFAOYSA-N.