L-Kynurenine

L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50 = 12.3 µM). It decreases intracellular concentrations of NAD+ (Cay-16077) in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner. L-Kynurenine in combination with IFN-gamma reduces lung injury induced by A. fumigatus infection in the p47phox-/- mouse model of chronic granulomatous disease.Formal Name: alphaS,2-diamino-gamma-oxo-benzenebutanoic acid. CAS Number: 2922-83-0. Synonyms: 3-anthraniloyl-Alanine, L-KYN. Molecular Formula: C10H12N2O3. Formula Weight: 208.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.5M HCl: 50 mg/ml. lambdamax: 229, 257, and 370 nm. SMILES: NC1=CC=CC=C1C(C[C@H](N)C(O)=O)=O. InChi Code: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1. InChi Key: YGPSJZOEDVAXAB-QMMMGPOBSA-N.