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Zu "K09093" wurden 107 Artikel gefunden!
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NEU
Artikelnummer: Cay36939-10
BAY-2416964 is an antagonist of the aryl hydrocarbon receptor (AhR, IC50 = 22 nM in U87 cells). It decreases the mRNA expression of the AhR target genes CYP1A1 and AHRR induced by the AhR agonist kynurenic acid (Cay-16792) in LPS-stimulated isolated human monocytes when used at a concentration of 100 nM. BAY-2416964...
Schlagworte: | 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-4-pyridazinecarboxamide |
Anwendung: | AhR antagonist |
CAS | 2242464-44-2 |
MW: | 387.8 D |
ab 80,00 €
Artikelnummer: ELK-ELK1891.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AhR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AhR. Next,...
Schlagworte: | AhR, bHLHe76, Ah receptor, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: IB-IB06001
INDIGO's Aryl Hydrocarbon Receptor (AhR) Reporter Cells include the luciferase reporter gene functionally linked to an AhR-responsive promoter. Thus, quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in AhR activity. The principle...
Schlagworte: | Aryl Hydrocarbon Receptor (human) Assay Kit, AHR, AhR, BHLHE76, bHLHe76, Ah receptor, Aryl hydrocarbon receptor, Class E... |
Anwendung: | Functional activity screening |
ab 1.448,00 €
Artikelnummer: Cay36527-10
Tapinarof is a stilbene that has been found in P. luminescens and has diverse biological activities. It is active against the fungi C. tropicales, C. neoformans, and A. fumigatus (MICs = 25, 12, and 12 µg/ml, respectively) and the plant pathogenic fungi A. flavus and B. cinerea (MICs = 25 and 12 µg/ml,...
Schlagworte: | Benvitimod, WBI-1001, 2-(1-methylethyl)-5-[(1E)-2-phenylethenyl]-1,3-benzenediol |
Anwendung: | Bioactive stilbene |
CAS | 79338-84-4 |
MW: | 254.3 D |
ab 68,00 €
Artikelnummer: Cay38392-1
2,3,7,8-Tetrachlorodibenzo-p-dioxin is a toxicant and an agonist of the aryl hydrocarbon receptor (AhR, ED50 = 0.2 nmol/kg in a reporter assay using chicken embryos). It also induces AhR ubiquitination and degradation in Hepa-1c1c7 hepatic cells when used at a concentration of 1 nM. Oral administration of...
Schlagworte: | 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin, 2,3,7,8-Tetrachlorodibenzodioxin, TCDBD, TCDD,... |
Anwendung: | AhR agonist, toxicant |
CAS | 1746-01-6 |
MW: | 322 D |
341,00 €
Artikelnummer: Cay11305-50
L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in...
Schlagworte: | 3-anthraniloyl-Alanine, alphaS,2-diamino-gamma-oxo-benzenebutanoic acid |
Anwendung: | AHR ligand |
CAS | 2922-83-0 |
MW: | 208.2 D |
ab 50,00 €
Artikelnummer: Cay10625-1
Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds...
Schlagworte: | SR1, 4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol |
Anwendung: | Aryl hydrocarbon receptor inhibitor |
CAS | 1227633-49-9 |
MW: | 429.5 D |
ab 39,00 €
Artikelnummer: Cay16924-1
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. alpha-Naphthoflavone is a flavone that modulates xenobiotic metabolism at...
Schlagworte: | 7,8-Benzoflavone, NSC 407011, 2-phenyl-4H-naphtho[1,2-b]pyran-4-one |
Anwendung: | AhR expression modulator |
CAS | 604-59-1 |
MW: | 272.3 D |
ab 39,00 €
Artikelnummer: Cay16476-1
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4'-methyl genistein, biochanin A can be metabolized in vivo...
Schlagworte: | 4'-methyl Genistein, 5,7-dihydroxy-4'-Methoxyisoflavone, NSC 123538, 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
Anwendung: | Phytoestrogen, AHR agonist |
CAS | 491-80-5 |
MW: | 284.3 D |
ab 48,00 €
Artikelnummer: Cay36307-1
L-Kynurenine-d4 is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to...
Schlagworte: | 3-anthraniloyl-Alanine-d4, L-KYN-d4, (S)-2-amino-4-(2-aminophenyl-3,5-d2)-4-oxobutanoic-3,3-d2 acid |
Anwendung: | GC-MS, LC-MS internal standard, quantification, AHR ligand |
CAS | 2672568-86-2 |
MW: | 212.2 D |
ab 75,00 €
Artikelnummer: Cay37583-10
BAY-218 is an aryl hydrocarbon receptor antagonist (AhR, IC50 = 39.9 nM). Preincubation with BAY-218 (1 µM) decreases AhR nuclear translocation induced by aflatoxin B1 (Cay-11293) in L-02 hepatocytes and TK6 lymphoblasts. BAY-218 (30 mg/kg), alone and in combination with an anti-PD-L1 antibody, reduces tumor growth...
Schlagworte: | BAY-2335218, 6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-4-pyridazinecarboxamide |
Anwendung: | AhR antagonist |
CAS | 2162982-11-6 |
MW: | 401.8 D |
ab 90,00 €
Artikelnummer: IB-EM06001
This Aryl Hydrocarbon Receptor Bioassay for Environmental Sample Monitoring kit is an all-inclusive luciferase reporter assay system that includes, in addition to AhR Reporter Cells, this kit includes are two optimized media for use during cell culture and in diluting the user's test samples, Luciferase Detection...
Schlagworte: | AhR, bHLHe76, Ah receptor, Aryl hydrocarbon receptor, Class E basic helix-loop-helix protein 76 |
Anwendung: | Functional activity screening |
Spezies-Reaktivität: | human |
1.448,00 €